In the past decade, the entrepreneurship literature has paid considerable attention to the health of entrepreneurs. Although the overall well-being and mental health can increase entrepreneurs’ performance, less attention has been paid to their physical health. This paper aims to advance existing research, which has mainly relied on self-reported measures of physical health, by introducing objective measures of physical health from which we can gain a deeper understanding of the relationships among physical health and entrepreneurial decision-making. This paper is a starting point and practical guide to encourage the inclusion of objective physical health measures in future entrepreneurship studies.