Similar QALY gain in primary and revision knee arthroplasty: A cost analysis and Markov model, in: Knee Surgery, Sports Traumatology, Arthroscopy
Journal
Knee Surgery, Sports Traumatology, Arthroscopy
Type
journal article
Date Issued
2025
Author(s)
Abstract
Purpose
The aim of this study is to investigate the cost‐effectiveness of revision total knee arthroplasty compared to primary total knee arthroplasty in terms of cost‐per‐quality‐adjusted life year (QALY).
Methods
Data were retrieved for all primary and revision total knee replacement (TKA) procedures performed at a tertiary Swiss hospital between 2006 and 2019. A Markov model was created to evaluate revision risk and we calculated lifetime QALY gain and lifetime procedure costs through individual EuroQol 5 dimension (EQ‐5D) scores, hospital costs, national life expectancy tables and standard discounting processes. Cost‐per‐QALY gain was calculated for primary and revision procedures.
Results
EQ‐5D data were available for 1343 primary and 103 revision procedures. Significant QALY gains were seen following surgery in all cases. Similar, but significantly more QALYs were gained following primary TKA (PTKA) (5.67 ± 3.98) than following revision TKA (RTKA) (4.67 ± 4.20). Cost‐per‐QALY was €4686 for PTKA and €10,364 for RTKA. The highest average cost‐per‐QALY was seen in two‐stage RTKA (€12,292), followed by one‐stage RTKA (€8982).
Conclusion
RTKA results in a similar QALY gain as PTKA. The costs of achieving health gain are two to three times higher in RTKA, but both procedures are highly cost‐effective.
Level of Evidence
Economic level II.
The aim of this study is to investigate the cost‐effectiveness of revision total knee arthroplasty compared to primary total knee arthroplasty in terms of cost‐per‐quality‐adjusted life year (QALY).
Methods
Data were retrieved for all primary and revision total knee replacement (TKA) procedures performed at a tertiary Swiss hospital between 2006 and 2019. A Markov model was created to evaluate revision risk and we calculated lifetime QALY gain and lifetime procedure costs through individual EuroQol 5 dimension (EQ‐5D) scores, hospital costs, national life expectancy tables and standard discounting processes. Cost‐per‐QALY gain was calculated for primary and revision procedures.
Results
EQ‐5D data were available for 1343 primary and 103 revision procedures. Significant QALY gains were seen following surgery in all cases. Similar, but significantly more QALYs were gained following primary TKA (PTKA) (5.67 ± 3.98) than following revision TKA (RTKA) (4.67 ± 4.20). Cost‐per‐QALY was €4686 for PTKA and €10,364 for RTKA. The highest average cost‐per‐QALY was seen in two‐stage RTKA (€12,292), followed by one‐stage RTKA (€8982).
Conclusion
RTKA results in a similar QALY gain as PTKA. The costs of achieving health gain are two to three times higher in RTKA, but both procedures are highly cost‐effective.
Level of Evidence
Economic level II.
HSG Classification
contribution to practical use / society
Refereed
Yes
Publisher
Wiley
Volume
33
Number
1
Subject(s)
Division(s)